Microsoft’s outlook service is down worldwide, affecting outlook on the web and outlook on desktop and mobile. The outage started at around 2am et, and Microsoft has confirmed it’s affecting users worldwide. Outlook users are currently unable to access their email, and Outlook.com is failing to load.

The outage appears to have been caused by a change on Microsoft’s end.’we’re reviewing recent changes to our service to further determine the cause of impact,’ says Microsoft’s 365 status Twitter account.

This is the second major Microsoft services outage in less than a week. On Monday Microsoft Outlook, Office 365, teams, and other services all experienced issues for hours.